2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Eukaryotic Initiation Factor (eIF)
  5. Eukaryotic Initiation Factor (eIF) Modulator

Eukaryotic Initiation Factor (eIF) Modulator

Eukaryotic Initiation Factor (eIF) Modulators (7):

Cat. No. Product Name Effect Purity
  • HY-114568
    AMC-01
    		Modulator 99.38%
    AMC-01 is a potent chemical probe that regulates eIF2-α activity. AMC-01 induces protein kinase RNA activation (PKR) kinase and nuclear factor κb (NF-κB). AMC-01 inhibits apoptosis.
  • HY-177074
    Comtifator
    		Modulator
    Comtifator (Example 77) is a modulator of the integrated stress response pathway. Comtifator can be studied in research for diseases associated with integrated stress response.
  • HY-158198
    PRXS571
    		Modulator
    PRXS571 is a potent modulator of the neuronal integrated stress response (ISR) and can be used in neural-related research.
  • HY-175877
    RAPT-37-Me
    		Modulator
    RAPT-37-Me is a GCN2-targeting agent with IC50 values of 0.002μM, ＞ 10 μM,4.40 μM and 1.31 μM for GCN2, PERK, HRl and PKR, respectively.
  • HY-164026
    ISR modulator-1
    		Modulator
    ISR modulator-1 (Compound 212) is a modulator for integrated stress response pathway (ISR)
  • HY-175878
    EMD-C02602
    		Modulator
    EMD-C02602 is a GCN2-targeting agent with IC50 values of 0.023 μM, 4.52 μM, ＞ 10 μM and 0.048 μM for GCN2, PERK, HRland PKR, respectively.
  • HY-175880
    AMG-34
    		Modulator
    AMG-34 is a GCN2-targeting agent with IC50 values of 0.395 μM, 0.010 μM, 1.07 μM and ＞ 10 μM for GCN2, PERK, HRland PKR, respectively.